Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress
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The development of a specific and sensitive low-volume assay for GLP-1(136)NH 2 will be required to clarify this possibility, but the similar profiles of glucagon, measured using a validated assay for pancreatic (as opposed to gut) glucagon, support the hypothesis that the early immunoreactive GLP-1 peak may be due to GLP-1(136)NH 2 from the pancreas